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∙ Iijima, M. .. Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps Estimating intracellular calcium concentrations and buffering without wavelength ratioing Csordás, G. ∙ Golenár, T. ∙ Seifert, E.L.
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.. MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter Analysis of variance designs for model output Variance based sensitivity analysis of model output. Design and estimator for the total sensitivity index Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropediatrics, 10117 Berlin, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Clinical Research Center, 10117 Berlin, Germany Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Faculty of Mathematics and Natural Sciences, Heinrich Heine University, 40225 Düsseldorf, Germany Computational Biology Group, Luxembourg Centre for Systems sildenafil premature ejaculation Biomedicine, University of Luxembourg, 4366 Esch-sur-Alzette, Luxembourg Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Institute of Applied Biosciences (INAB), Centre For Research and Technology Hellas (CERTH), 57001 Thessaloniki, Greece Department of Physics, University of South Florida, Tampa, FL 33620, USA Stem Cells and Metabolism Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland Institute of Neurobiology, Heinrich Heine University, 40225 Düsseldorf, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Faculty of Mathematics and Natural Sciences, Heinrich Heine University, 40225 Düsseldorf, Germany Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands Department of Pediatrics, Amalia Children’s Hospital, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands Institute of Neurobiology, Heinrich Heine University, 40225 Düsseldorf, Germany Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Stem Cells and Metabolism Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126 Milan, Italy Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of Molecular Biology & CMBI, Genomics, Stem Cell & Regenerative Medicine Group, University of Innsbruck, 6020 Innsbruck, Austria Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany Experimental Cardiology Institute, Medical Clinic I/Cardiology and Angiology, Justus Liebig University of Giessen, 35392 Giessen, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4366 Esch-sur-Alzette, Luxembourg Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropediatrics, 10117 Berlin, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Department of Biology, University of Padova, 35121 Padova, Italy Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, 40139 Bologna, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, 40139 Bologna, Italy Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of Medicine, Section of Immunology, University of Verona Hospital Trust, 37134 Verona, Italy Department of Medicine, Section of Immunology, University of Verona Hospital Trust, 37134 Verona, Italy Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands Department of Medical BioSciences, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany German Center for Cardiovascular Research (DZHK), partner site Lower Saxony and Berlin, 10785 Berlin, Germany Department of Pediatrics and Adolescent Medicine, University Medical Center, Georg-August-University, 37075 Göttingen, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Department of Pediatrics and Adolescent Medicine, University Medical Center, Georg-August-University, 37075 Göttingen, Germany German Center for Child and Adolescent Health (DZKJ), Section CNS Development and Neurological Disease, partner site Göttingen, Robert-Koch-Str. Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany Department of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany Institute of Neurobiology, Heinrich Heine University, 40225 Düsseldorf, Germany Institute of Applied Biosciences (INAB), Centre For Research and Technology Hellas (CERTH), 57001 Thessaloniki, Greece Department of Molecular Biology & CMBI, Genomics, Stem Cell & Regenerative Medicine Group, University of Innsbruck, 6020 Innsbruck, Austria Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands Department of Pediatrics, Amalia Children’s Hospital, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands Human and Animal Physiology, Wageningen University, 6708 WD Wageningen, the Netherlands Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany Neuropsychiatry and Laboratory of Molecular Psychiatry, Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Jastrzebiec n/Warsaw, Poland Stem Cells and Metabolism Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland HiLife, University of Helsinki, 0004 Helsinki, Finland HUS Diagnostics, Helsinki University Hospital, 00290 Helsinki, Finland Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126 Milan, Italy Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, 20122 Milan, Italy Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4366 Esch-sur-Alzette, Luxembourg IKERBASQUE, Basque Foundation for Science, 48009 Bilbao, Spain CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, 48160 Derio, Spain Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropediatrics, 10117 Berlin, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Clinical Research Center, 10117 Berlin, Germany German Center for Child and Adolescent Health (DZKJ), Section CNS Development and Neurological Disease, partner site Berlin, 13353 Berlin, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany The content on this site is intended for healthcare professionals and researchers across all fields of science. ∙ Calabrese, F.M...
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HmtDB, a genomic resource for mitochondrion-based human variability studies The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 Stem Cell Rep.
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2022; 17:307-320 Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells Stem Cell Rep.
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S1 Fig. Western blot of p-ERK1/2 in the RV myocardium.
2017; 8:894-906 A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ Bertram, R.
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Two-day LV pressure overload (TAC) did not affect RV pressure or function, but prolonged LV relaxation that was ameliorated by sildenafil
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A simplified model for mitochondrial ATP production Model of beta-cell mitochondrial calcium handling and electrical activity. Actin-based confinement of calcium responses during Shigella invasion Contreras, L. ∙ Gomez-Puertas, P.
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.. Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps Estimating intracellular calcium concentrations and buffering without wavelength ratioing Csordás, G.
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∙ Piredda, R. ∙ Calabrese, F.M... HmtDB, a genomic resource for mitochondrion-based human variability studies The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 Stem Cell Rep. 2022; 17:307-320 Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells Stem Cell Rep. 2017; 8:894-906 A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ Bertram, R.
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∙ Gram Pedersen, M. ∙ Luciani, D.S... A simplified model for mitochondrial ATP production Model of beta-cell mitochondrial calcium handling and electrical activity. Actin-based confinement of calcium responses during Shigella invasion Contreras, L. ∙ Gomez-Puertas, P. ∙ Golenár, T.
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ERK and calcineurin were activated in the RV as well as in the LV, and were inhibited by sildenafil treatment
∙ Seifert, E.L. .. MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter Analysis of variance designs for model output Variance based sensitivity analysis of model output.
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Design and estimator for the total sensitivity index Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropediatrics, 10117 Berlin, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Clinical Research Center, 10117 Berlin, Germany Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Faculty of Mathematics and Natural Sciences, Heinrich Heine University, 40225 Düsseldorf, Germany Computational Biology Group, Luxembourg Centre for Systems sildenafil premature ejaculation Biomedicine, University of Luxembourg, 4366 Esch-sur-Alzette, Luxembourg Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Institute of Applied Biosciences (INAB), Centre For Research and Technology Hellas (CERTH), 57001 Thessaloniki, Greece Department of Physics, University of South Florida, Tampa, FL 33620, USA Stem Cells and Metabolism Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland Institute of Neurobiology, Heinrich Heine University, 40225 Düsseldorf, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Faculty of Mathematics and Natural Sciences, Heinrich Heine University, 40225 Düsseldorf, Germany Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands Department of Pediatrics, Amalia Children’s Hospital, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands Institute of Neurobiology, Heinrich Heine University, 40225 Düsseldorf, Germany Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Stem Cells and Metabolism Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126 Milan, Italy Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of Molecular Biology & CMBI, Genomics, Stem Cell & Regenerative Medicine Group, University of Innsbruck, 6020 Innsbruck, Austria Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany Experimental Cardiology Institute, Medical Clinic I/Cardiology and Angiology, Justus Liebig University of Giessen, 35392 Giessen, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4366 Esch-sur-Alzette, Luxembourg Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropediatrics, 10117 Berlin, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Department of Biology, University of Padova, 35121 Padova, Italy Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, 40139 Bologna, Italy IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, 40139 Bologna, Italy Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Department of Medicine, Section of Immunology, University of Verona Hospital Trust, 37134 Verona, Italy Department of Medicine, Section of Immunology, University of Verona Hospital Trust, 37134 Verona, Italy Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands Department of Medical BioSciences, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands Institute of Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, 37075 Göttingen, Germany German Center for Cardiovascular Research (DZHK), partner site Lower Saxony and Berlin, 10785 Berlin, Germany Department of Pediatrics and Adolescent Medicine, University Medical Center, Georg-August-University, 37075 Göttingen, Germany Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, 37037 Göttingen, Germany Department of Pediatrics and Adolescent Medicine, University Medical Center, Georg-August-University, 37075 Göttingen, Germany German Center for Child and Adolescent Health (DZKJ), Section CNS Development and Neurological Disease, partner site Göttingen, Robert-Koch-Str. Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany Department of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany Institute of Neurobiology, Heinrich Heine University, 40225 Düsseldorf, Germany Institute of Applied Biosciences (INAB), Centre For Research and Technology Hellas (CERTH), 57001 Thessaloniki, Greece Department of Molecular Biology & CMBI, Genomics, Stem Cell & Regenerative Medicine Group, University of Innsbruck, 6020 Innsbruck, Austria Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands Department of Pediatrics, Amalia Children’s Hospital, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands Human and Animal Physiology, Wageningen University, 6708 WD Wageningen, the Netherlands Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115 Berlin, Germany Neuropsychiatry and Laboratory of Molecular Psychiatry, Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Jastrzebiec n/Warsaw, Poland Stem Cells and Metabolism Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland HiLife, University of Helsinki, 0004 Helsinki, Finland HUS Diagnostics, Helsinki University Hospital, 00290 Helsinki, Finland Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126 Milan, Italy Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, 20122 Milan, Italy Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4366 Esch-sur-Alzette, Luxembourg IKERBASQUE, Basque Foundation for Science, 48009 Bilbao, Spain CIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, 48160 Derio, Spain Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropediatrics, 10117 Berlin, Germany Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, NeuroCure Clinical Research Center, 10117 Berlin, Germany German Center for Child and Adolescent Health (DZKJ), Section CNS Development and Neurological Disease, partner site Berlin, 13353 Berlin, Germany Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-Düsseldorf, 40225 Düsseldorf, Germany The content on this site is intended for healthcare professionals and researchers across all fields of science.