Understanding Cialis: The Lilly Brand Medication

Computed from IMS NPA PlusTM, April 2004.

About the Company

Headquartered in Indianapolis, Ind., Lilly provides answers - through medicines and information - for some of the world's most urgent medical needs. Additional information about Lilly is available at ICOS Corporation, a biotechnology company, is dedicated to bringing innovative therapeutics to patients. Headquartered in Bothell, Wash., ICOS is marketing its first product, Cialis (tadalafil), for the treatment of erectile dysfunction. ICOS is working to develop treatments for serious unmet medical conditions such as chronic obstructive pulmonary disease, cancer and inflammatory diseases. B-roll is available via satellite, C-band feed: WEDNESDAY, JUNE 2, 10:30 - 11:00 AM EDT C-Band, IA 6, Tr.

How Long Does It Take For Results?

WEDNESDAY, JUNE 2, 13:15 - 13:45 PM EDT C-Band, IA 5, Tr. THURSDAY, JUNE 3, 13:00 - 13:30 PM EDT C-Band, IA 5, Tr. Except for historical information contained herein, this press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on current expectations, estimates and projections about the industry, management beliefs and certain assumptions made by the management of ICOS and Lilly. Investors are cautioned that matters subject to forward-looking statements involve risks and uncertainties, including economic, competitive, governmental, technological, legal and other factors discussed in the two companies' respective filings with the Securities and Exchange Commission, which may affect the business and prospects of the two companies and Lilly ICOS.

Can I buy Cialis without a prescription?

Results and the timing and outcome of events may differ materially from those expressed or implied by the forward-looking statements in this press release. More specifically, there can be cheap cialis canada online no assurance that Cialis will achieve commercial success or that competing products will not pre-empt market opportunities that might exist for the product. Cialis® is a registered trademark of Lilly ICOS LLC. All other trademarks are the property of their respective owners. Viagra® is a registered trademark of Pfizer, Inc. The Likely Worldwide Increase in Erectile Dysfunction Between 1995 and 2025 and Some Possible Policy Consequences. Back To Great Sex: Overcome ED and Reclaim Lost Intimacy.

Product	Dosage	Quantity + Bonus	Price
Cialis Generic	20mg	30 + 4 Pills	68.05€ 64.81€	Buy
Cialis Generic	60mg	20 Pills	65.61€ 62.49€	Buy
Cialis Professional	40mg	20 Pills	110.24€ 104.99€	Buy
Cialis Generic	5mg	20 Pills	41.99€ 39.99€	Buy
Cialis Black	80mg	10 Pills	43.27€ 41.21€	Buy
Cialis Generic	2.5mg	30 + 4 Pills	51.95€ 49.48€	Buy
Cialis Generic	40mg	90 + 6 Pills	171.35€ 163.19€	Buy
Cialis Generic	20mg	20 Pills	54.72€ 52.11€	Buy
Cialis Soft Tabs	20mg	90 + 6 Pills	216.71€ 206.39€	Buy
Cialis Soft Tabs	20mg	180 + 8 Pills	353.17€ 336.35€	Buy
Cialis Generic	20mg	10 Pills	31.49€ 29.99€	Buy
Cialis Original	20mg	8 Pills	61.70€ 58.76€	Buy
Cialis Professional	20mg	360 + 6 Pills	807.03€ 768.60€	Buy
Cialis Professional	40mg	120 + 4 Pills	436.68€ 415.89€	Buy
Cialis Generic	20mg	90 + 6 Pills	154.71€ 147.34€	Buy
Cialis Generic	40mg	180 + 10 Pills	277.29€ 264.09€	Buy
Cialis Generic	40mg	120 + 8 Pills	206.98€ 197.12€	Buy

Singapore, 5 February 2024 Zuellig Pharma, a leading healthcare solutions company in Asia, has announced that it has completed the acquisition of two brands, Cialis® (Tadalafil) and Alimta® (Pemetrexed), from Eli Lilly and Company (“Lilly”) for select ASEAN markets, including Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines and Thailand, via its wholly-owned subsidiary, Zanovex Pte.

Cialis vs. Tadalafil: Frequently Asked Questions

The term "new treatment initiations" indicates when a physician writes out a new prescription for patients never before treated, and for patients switching from one product to another. This does not include prescriptions conveyed to pharmacies by phone or refills of existing prescriptions. In this release, new treatment initiations describes data from ImpactRx only. ImpactRx™ has a panel of high prescribing physicians that recorded information on patient visits (patient identity is non-identifiable), including diagnosis and treatment. ImpactRx data includes new prescriptions written and refills but not prescriptions conveyed by phone.

Manufacturers’ Strategies

ImpactRx records information from the physician perspective and not what happens at the pharmacy. Computed from IMS NPA Plus™, April 2004. IMS numbers vary from those of ImpactRx primarily because IMS data represent aggregated pharmacy sales, reflecting what is filled at the pharmacy including new prescriptions for continuing users and prescriptions called in by phone. "The Three PDE 5 Inhibitors Sildenafil, Tadalafil And Vardenafil - Results Of A Comparative Preference Trial In 222 Patients With Erectile Dysfunction," Hartmut Porst, et. al., presented in poster session at American Urological Association Annual Meeting, May 2004. Zanovex will own the trademarks and marketing authorisations, and license manufacturing know-how for Alimta®, an established chemotherapy drug for the treatment of a certain type of non-small cell lung cancer and malignant pleural mesothelioma, and Cialis®, a leading men’s health product for the treatment of erectile dysfunction.

Region	Average Price per 20 mg Tablet	Brand Name Price	Discount Options	Availability of Generics
USA	$40	Cialis	Coupons, insurance	Limited generics
Europe	€35	Cialis E.C.	Bulk discounts	Several generics
India	₹150	Cialis Lilly	Local pharmacies	Widely available
Australia	AU$50	Cialis	Pharmacy discounts	Generics available

ZP Therapeutics, the commercial division of Zuellig Pharma, will promote the two brands in the relevant markets.

• Cialis Lilly’s tadalafil works by inhibiting the PDE5 enzyme that restricts blood flow.
• Its extended window allows sexual activity without strict timing constraints.
• Clinical trials demonstrate significant improvements in erectile function.
• Cialis Lilly is often preferred due to fewer visual side effects versus alternatives.
• Combining alcohol with Cialis Lilly is not recommended as it may lower blood pressure.
• The brand is commitment-driven to ongoing research and development.
• Generic tadalafil products exist but Lilly’s brand emphasizes consistent dosing.
• Cialis Lilly supports patient adherence through convenient packaging.
• It is sometimes used off-label under medical guidance for pulmonary arterial hypertension.
• Cost and insurance coverage vary depending on country and provider.

Prior to the acquisition, ZP Therapeutics was responsible for the promotion and distribution of the brands as part of a broader, long-term strategic partnership with Lilly in Brunei, Indonesia, Malaysia, Philippines and Thailand.

What Are the Key Risks and Uncertainties?

In fact, Cialis represented 56 percent of new treatment initiations by urologists in April, compared to 21 percent for Levitra (vardenafil HCl)5 and 23 percent for Viagra.6 Based on data from IMS, another source of market information, in April, Cialis represented 30 percent of new ED treatment prescriptions written by urologists, compared to 16 percent for Levitra and 54 percent for Viagra.7 In April, nearly two thirds of all men who switched their oral ED treatment switched to Cialis. Following is information from ImpactRx™ on share of new prescriptions written in April by doctors changing their patients' ED treatment from product to another. In an independent clinical study, more men selected Cialis as their preferred treatment of choice after trying different oral ED medications, primarily because of how long the drug worked.8 This may explain why many men with ED who are on oral treatment are switching to Cialis. The percentages of new prescriptions written by all doctors for oral ED treatments in April broke out as follows: Cialis, 19 percent; Levitra, 14 percent; and Viagra, 67 percent.9 "The early success of Cialis in the U.S. is similar to the trend we saw when it first became available in other countries.

What happens if a woman takes Cialis?

Cialis has claimed market shares of 19 percent to 39 percent across Europe, and even higher in some other markets," said Leonard Blum, vice president of marketing, ICOS Corporation. In the first quarter of 2004, Cialis achieved $108 million in global sales. More than two million men around the world have been treated with Cialis since its first introduction globally last year. "For us, the number of Cialis prescriptions written by urologists is one of the most important indicators of future trends. Urologists are the experts in treating ED.

Does Cialis make you last longer?

We expected that urologists would be the quickest adopters of Cialis, and the data suggest that these specialists, like their peers overseas, are making Cialis their preferred treatment," said Blum. Cialis is changing the way doctors and patients think about treating ED by offering two important benefits: a 36-hour window of opportunity for intimacy and the ability to take the tablet on an empty stomach or with a meal, without concern that high-fat food will reduce the absorption of the medicine. "What the marketplace tells us is that men and their partners are truly taking advantage of the benefits of Cialis," said Matt Beebe, U.S. brand team leader for Cialis, Lilly ICOS LLC. "Men can take Cialis Friday evening and choose the moment for romance as late as Sunday morning. “This acquisition marks a major milestone in the evolution of Zuellig Pharma to becoming an integrated healthcare solutions company.

• Cialis Lilly is part of a broader portfolio by Eli Lilly that addresses several medical conditions.
• Its patent expiration has led to more affordable generics entering the market.
• Lilly maintains stringent manufacturing standards for Cialis products.
• Patients should disclose all medications and health conditions before starting Cialis.
• The brand conducts patient assistance programs for affordability in some regions.
• Cialis Lilly tablets are scored for easy splitting if needed to adjust dose.
• Erectile dysfunction can also be influenced by psychological factors; Cialis addresses physical causes.
• Cialis Lilly must be taken cautiously in patients with heart conditions.
• Regular medical follow-up is recommended to monitor effectiveness and safety.
• Cialis Lilly promotes balanced lifestyle as part of overall ED management.

We look forward to further expanding our commercial presence in the region through meaningful strategic partnerships with the world’s leading biopharma companies as we remain focused on our purpose of making healthcare more accessible to communities in Asia,” said John Graham, Group CEO, Zuellig Pharma.

Companies anticipate providing over-the-counter (OTC) product to treat erectile dysfunction after expiration of certain patents

Because Cialis works for up to 36 hours, it allows a man and his partner to relax, forget about planning intimacy and let it happen order cialis online without a prescription when the moment is right for them." Cialis, approved by the FDA in November 2003 for the treatment of erectile dysfunction, is the only oral ED treatment shown to improve erectile function up to 36 hours in most men. The absorption of Cialis is not reduced by food, including high-fat foods. Cialis is currently available in more than 60 countries, including Australia, Brazil, Mexico, Canada, the United States and countries throughout Europe. More than two million patients worldwide have been treated with Cialis since its first introduction in February 2003. Cialis is available by prescription only and is not for everyone.

Side Effects of Cialis:

Men taking nitrates, often used for chest pain, or certain alpha-blockers for prostate problems or high blood pressure, should not take Cialis. Such combinations could cause a sudden, unsafe drop in blood pressure. Men should discuss their health status with their doctors to ensure Cialis is right for them and that they are healthy enough for sexual activity. The most common side effects with Cialis were headache, upset stomach, delayed backache and muscle ache. Although rare, men who experience an erection for more than four hours should seek immediate medical attention.

2. They Have Different Price Points

Men should not drink alcohol in excess with Cialis. Cialis studies were not designed to assess multiple intercourse attempts after a single dose. ED is defined as the consistent inability to attain and maintain an erection sufficient for sexual intercourse. ED affects an estimated 152 million men and their partners worldwide.10 Experts believe that 80 - 90 percent of ED cases are related to a physical or medical condition, like diabetes, cardiovascular diseases, and prostate cancer treatment, while 10 - 20 percent are due to psychological causes.11,12 In many cases, however, both psychological and physiological factors contribute to the condition.13 Lilly ICOS LLC, a joint venture between ICOS Corporation and Eli Lilly and Company, developed tadalafil for the treatment of erectile dysfunction. Lilly, a leading innovation-driven corporation is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations.